Creatine (2024)

Adhihetty PJ, Beal MF. Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases. Neuromolecular Med. 2008;10(4):275-90. Epub 2008 Nov 13. Review.

Aguiar AF, Januario RS, Junior RP, et al. Long-term creatine supplementation improves muscular performance during resistance training in older women. Eur J Appl Physiol. 2013;113(4):987-996.

Beck TW, Housh TJ, Johnson GO, Coburn JW, Malek MH, Cramer JT. Effects of a drink containing creatine, amino acids, and protein combined with ten weeks of resistance training on body composition, strength, and anaerobic performance. J Strength Cond Res. 2007;21(1):100-104.

Bender A, Koch W, Elstner M, et al. Creatine supplementation in Parkinson disease: a placebo-controlled randomized pilot trial. Neurology. 2006;67(7):1262-1264.

Bender A, Samtleben W, Elstner M, Klopstock T. Long-term creatine supplementation is safe in aged patients with Parkinson disease. Nutr Res. 2008;28(3):172-178.

Benzi G. Is there a rationale for the use of creatine either as nutritional supplementation or drug administration in humans participating in a sport? Pharmacol Res. 2000;41(3):255-264.

Cancela P, Ohanian C, Cuitiño E, Hackney AC. Creatine supplementation does not affect clinical health markers in football players. Br J Sports Med. 2008;42(9):731-735.

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Do I Need To Cycle Creatine?

Gualano B, de Salles Painelli V, Roschel H, et al. Creatine supplementation does not impair kidney function in type 2 diabetic patients: a randomized, double-blind, placebo-controlled, clinical trial. Eur J Appl Physiol. 2011;111(5):749-756.

Hass CJ, Collins MA, Juncos JL. Resistance training with creatine monohydrate improves upper-body strength in patients with Parkinson disease: a randomized trial. Neurorehabil Neural Repair. 2007;21(2):107-115.

Kingsley M, Cunningham D, Mason L, Kilduff LP, McEneny J. Role of creatine supplementation on exercise-induced cardiovascular function and oxidative stress. Oxid Med Cell Longev. 2009;2(4):247-254.

Kley RA, Tarnopolsky MA, Vorgerd M. Creatine for treating muscle disorders. Cochrane Database Syst Rev. 2013;(6):CD004760.

Korzun WJ. Oral creatine supplements lower plasma hom*ocysteine concentrations in humans. Clin Lab Sci. 2004;17(2):102-106.

McMorris T, Harris RC, Swain J, et al. Effect of creatine supplementation and sleep deprivation, with mild exercise, on cognitive and psychom*otor performance, mood state, and plasma concentrations of catecholamines and cortisol. Psychopharmacology (Berl). 2006;185(1):93-103.

Metzl JD, Small E, Levine SR. Gershel JC. Creatine use among young athletes. Pediatrics. 2001;108(2):421-425.

Patra S, Ghosh A, Roy SS, et al. A short review on creatine-creatine kinase system in relation to cancer and some experimental results on creatine as adjuvant in cancer therapy. Amino Acids. 2012;42(6):2319-2330.

Persky AM, Rawson ES. Safety of creatine supplementation. Subcell Biochem. 2007;46:275-289. Review.

Sheth NP, Sennett B, Berns JS. Rhabdomyolysis and acute renal failure following arthroscopic knee surgery in a college football player taking creatine supplements. Clin Nephrol. 2006;65(2):134-137.

Simon DK, Wu C, Tilley BC, et al. Caffeine and progression of Parkinson disease:a deleterious interaction with creatine. Clin Neuropharmacol. 2015;38(5):163-169.

Sullivan PG, Geiger JD, Mattson MP, Scheff SW. Dietary supplement creatine protects against traumatic brain injury. Ann Neurol. 2000;48(5):723-729.

Tarnopolsky MA, Beal MF. Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders [Review]. Ann Neurol. 2001;49(5):561-574.

Tyler TF, Nicholas SJ, Hershman EB, Glace BW, Mullaney MJ, McHugh MP. The effect of creatine supplementation on strength recovery after anterior cruciate ligament (ACL) reconstruction: a randomized, placebo-controlled, double-blind trial. Am J Sports Med. 2004;32(2):383-388.

Willer B, Stucki G, Hoppeler H, Bruhlmann P, Krahenbuhl S. Effects of creatine supplementation on muscle weakness in patients with rheumatoid arthritis. Rheumatology. 2000;39(3):293-298.

Witte KK, Clark AL, Cleland JG. Chronic heart failure and micronutrients. J Am Coll Cardiol. 2001;37(7):1765-1774.

FAQs

Creatine? ›

Studies show you only need 3 to 5 grams⁴ of daily, long-term creatine supplementation to keep muscle cells sufficiently saturated.

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Is 10g of creatine a day too much? ›

Lower doses up to 4-5 grams daily for up to 18 months have also been safely used. Creatine is possibly safe when taken long-term. Doses up to 10 grams daily for up to 5 years have been safely used. Side effects might include dehydration, upset stomach, and muscle cramps.

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What happens if you take 20g of creatine every day? ›

Creatine is a safe, well-studied supplement. Studies in a variety of people have shown no detrimental health effects of taking creatine supplements in doses up to 4–20 grams per day for 10 months to 5 years ( 19 , 20 , 21 ).

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Is 1000mg of creatine too much? ›

Too much creatine would be useless. If taken regularly, creatine may cause stomach discomfort and nausea. After the body fully absorbed creatine, it is recommended that the patient use three to five grams per day (15 mg/pound of the body weight) daily to maintain optimal muscle mass.

Source	Amount of Creatine (milligrams)
Provolone cheese ( 1 oz)	76 mg
Shrimp (3 oz)	20 mg
Milk (4 oz)	13 mg
Eggs (2 eggs)	10 mg

How much bigger does creatine make you? ›

How much bigger does creatine make you? It depends on your exercise routine. But some studies show that people who take creatine supplements may gain an extra two to four pounds of muscle mass during four to 12 weeks of regular exercise than people who don't take creatine.

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How to maximize creatine results? ›

To maximize muscle stores quickly, a creatine loading phase of 20–25 g daily for 5–7 days is recommended, followed by a maintenance dose of 3–5 g per day.

How much creatine is in steak? ›

A 2-pound steak only has about 5 grams of creatine in it. Five grams of the supplement form of creatine fit in a teaspoon. Thus, supplementing with creatine allows us to significantly increase the creatine levels in our cells without the burden of eating large quantities of meat.

What is the optimal creatine dosing? ›

Creatine is best supplemented in forms of monohydrate with daily intakes of 3-5 g, or for optimal absorption, 20 g divided into 4 daily intakes of 5 g in combination with carbohydrate and protein. Carbohydrate supplementation before exercise is essential to improve exercise performance.

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Is 3g of creatine better than 5g? ›

So, the body needs to replenish between 2–3 g of creatine per day to maintain creatine stores depending on muscle mass. To maintain saturation levels, taking between 3 to 5g per day is sufficient to do this in most people. If you have a larger amount of muscle mass then you may want to aim towards the higher end.

Should I take creatine on rest days? ›

Yes, creatine should be taken even on rest days. Consistent intake ensures your body has sufficient creatine reserves for your workout days and skipping its consumption on off days could limit its availability for your next workout.

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How many grams of creatine for overload? ›

The loading phase can mean consuming up to 20-25g per day in multiple 5g doses; however, the research shows that consuming more than 25g does not show any significant impact. So, overloading might just be an expensive way to have to urinate more...

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Is 3g creatine daily enough? ›

Based on the results, the researchers concluded that 3g per day is a sufficient dose for most lifters. This makes sense, given that studies have shown a significant improvement in performance from creatine supplementation with dosages of around 0.03g/kg/day.

Can I take 5000 mg of creatine a day? ›

The answer is that you should take 5 grams (5000mg) of Creatine daily, no more, no less. Five grams is, by far, the best dosage you can take if you want the supplement to work its wonders. This dose will provide your body with optimal creatine levels, leading to numerous performance benefits.

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Creatine (2024)

FAQs

Creatine? ›

How much bigger does creatine make you? ›

References